The O'Fallon Chamber of Commerce works to encourage economic growth and provide networking opportunities for businesses in O'Fallon and the rest of the St. Charles County region. Monthly meetings are on the fourth Tuesday of every month at varied locations. The chamber hosts regular luncheons for members, featuring a sponsors and speakers geared towards helping businesses thrive. It also hosts annual events, including the Art and Wine Gala, Firecracker 5K and a golf outing. Members are required to have an active business license and annual dues are dependent on the number of employees, and range from $220 to $1,200.