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Walgreen Drug Stores
9495 Mexico Rd, O Fallon, MO 63366
This is not a 24 hour store but it does stay open until 10 pm every day. Like all Walgreens locations, it has a wideMore selection of health and beauty supplies. This store also has a small grocery section that stocks the basics, like milk, eggs and butter. It is located at the corner of Bryan Road and Mexico.
1490 Mexico Loop Rd E, O Fallon, MO 63366
This 24-hour drug store offers online prescription ordering and drive-through pharmacy, photo department (digital printsMore and film roll processing), Redbox DVD rental and liquor department with wine and beer. Flu shots are also available, with no appointment necessary. You can check for weekly specials and print coupons by visiting the Walgreens Web site.
Walgreens Pharmacy
2920 Highway K, O Fallon, MO 63368
This Walgreens Pharmacy offers a Take Care Clinic and flu shots, and is open 24 hours. It carries makeup,More perfume and other personal items. It has a drive-though window for customer convenience.
7422 Highway N, O Fallon, MO 63368
This Walgreens is located at the corner of Highway N and Winghaven Blvd. It carries medical necessities and everydayMore essentials like shampoo, deodorant, vitamins and Kleenex.  It has a DVD red box and photo services. This is not a 24-hour store, but it does have convenient shopping hours.
4650 Highway K, O Fallon, MO 63368

This Walgreens is conveniently located on the corner of HighwayK and Technology drive near Highway 40. The storeMore sells basic household items, groceries, health and beauty products, pet care products, electronics, office supplies, greeting cards and over-the-counter medications.

This location has a full-service pharmacy with a drive-through window. The store also offers digital photo pick up, printer cartridge refills, online ordering, Redbox DVD rentals and a liquor department.

Blockbuster Video
929 N Main St, O Fallon, MO 63366
This Blockbuster is part of a national chain that rents movies. It also sells previously viewed movies as well asMore snacks. Blockbuster is located across from Walgreens on North Main Street.
Madison's Cafe
2974 Highway K, O Fallon, MO 63368
Madison's Cafe, conveniently located on the corner of Highways K and N behind Walgreens, boasts the longest happy hourMore in town, from 4pm to 9pm Monday through Friday. Its cozy atmosphere and reasonable prices makes it a great dining place for families as well as groups. Madison's also offers catering and a banquet room which seats up to 40 people. Brunch is offered on Sundays from 10am to 2pm.   
Advance America
1254 Bryan Rd, O Fallon, MO 63366
Advance America is conveniently located on Bryan Road next to Walgreens. It offers cash advance loans, prepaid VisaMore cards, check to card service and money grams. Your prepaid Visa can act as a bank account as it allows you to have your payroll check directly deposited to your card. It offers payday loans of up to $500 for a two-week term for a fee of $95.